Deep tissue massages can do a lot to relieve pain, but also heat therapy can help quite significantly with both easing the pain and relaxing the muscle back into its proper resting shape. Generally, hot stone massages can be highly effective in taking care of knots. They aren’t generally serious and for less serious pain in lieu of a professional massage of the affected areas, anti-inflammatory medicine like ibuprofen can alleviate some of the pain, though won’t actually ‘cure’ a knot. Sometimes they will go away on their own, other times they will persist, but there’s not a lot of sure-fire things that can be said about what one can do. It’s best to seek therapeutic massage if you really want to ‘fix’ the pain and get back to your life.